Ipamorelin - British Dragon

Buy Ipamorelin 5 mg vials by British Dragon at XSteroids. Ipamorelin is the selective growth hormone secretagogue that releases GH without disturbing cortisol or prolactin, supplied by British Dragon as a lyophilized 5 mg vial that is dissolved before use. This page covers what it is, the human pharmacokinetics behind it, how a 5 mg vial calculates and how to store it.

Ipamorelin is not an approved medicine; sold here it is a research product and the notes below are educational.

What Ipamorelin Is

Ipamorelin is a pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2, developed from GHRP-1 and catalogued as NNC 26-0161. It is one of the smallest ghrelin receptor agonists in use, and it works the way a secretagogue should: it signals the pituitary to release growth hormone rather than supplying the hormone from outside. In research animals it also supported body weight gain, and in rats it induced longitudinal bone growth.

The Human Pharmacokinetics

Most peptides in this category come with animal data only. Ipamorelin does not. It was profiled in healthy male volunteers at five infusion rates from 4.21 to 140.45 nmol/kg over 15 minutes. The response was dose-proportional, the terminal half-life was about 2 hours, clearance was 0.078 l/h/kg and the volume of distribution at steady state was 0.22 l/kg. Growth hormone peaked at 0.67 hours and then fell away exponentially, with a half-maximal GH concentration of 214 nmol/l.

The two-hour half-life is the number that shapes everything else about it: each injection is one pulse of growth hormone rather than a sustained level.

What Makes It Selective

This is the detail that separates ipamorelin from the older GHRPs. In receptor profiling it does not raise ACTH or cortisol and does not change prolactin, FSH, LH or TSH, and that held at doses more than 200 times the effective dose for growth hormone. GHRP-2 and GHRP-6 do not show that separation. Selectivity is the whole selling point here, and it is one of the few claims in this group that rests on a measured receptor profile rather than a story.

How a 5 mg Vial Calculates

The brand instruction is 1 to 2 ml of bacteriostatic water for the 5 mg vial, giving 2.5 to 5 mg per ml. At 2 ml the vial is 2500 mcg per ml and 0.1 ml is 250 mcg; on a U-100 syringe that 0.1 ml is 10 units. At 1 ml the vial is 5000 mcg per ml and 0.1 ml draws 500 mcg.

• At 300 mcg a day one vial lasts about 16 days
• At 600 mcg a day about 8 days
• At 900 mcg a day, three 300 mcg doses, about 5.5 days

Vendor research doses are 200 to 300 mcg per injection as standard and 400 to 500 mcg for the advanced version, once to three times a day, over 12 to 16 week cycles with a 4 week break. In the human studies the drug was given as an intravenous infusion measured in nmol/kg, not as subcutaneous micrograms, so those microgram figures are vendor convention rather than a validated schedule.

Ipamorelin vs Sermorelin and CJC-1295

These get compared because they push the same axis from different ends. Ipamorelin is a ghrelin receptor agonist, while Sermorelin is a GHRH analogue and Tesamorelin is a stabilised GHRH analogue. Different receptors, the same output, which is why the two approaches are usually discussed together rather than as substitutes.

Timing and an Empty Stomach

The brand describes subcutaneous use on an empty stomach, often before sleep: about 2 hours after eating and at least 30 minutes before the next meal. The logic follows from the half-life. A food-driven insulin and glucose rise blunts a growth hormone pulse, so the injection is placed where the pulse has room to happen. Natural GH release is also highest in deep sleep, which explains the evening timing.

Storage and Reconstitution

Keep the powder at 15 to 25 C, or at 2 to 8 C for longer storage, and do not freeze it. Once dissolved, store at 2 to 8 C and use within 30 days, avoiding repeated freeze-thaw cycles. The brand gives this as its general rule for lyophilized peptides.

Side Effects and WADA Status

Vendor copy calls the profile clean, and the measured selectivity supports the cortisol and prolactin part of that. Class-level data for unregulated GH peptides is broader: possible prolactin and cortisol shifts, appetite changes, blood sugar changes, fluid retention, joint and muscle aches, and injection site reactions. Ipamorelin is prohibited in sport: WADA lists growth hormone secretagogues in class S2 of the 2026 list, which means at all times.

Other Peptides in the Line

For repair work the same brand carries BPC 157, TB 500 and GHK-Cu 50 mg, and for metabolic research there is MOTS-c.

Why Buy Ipamorelin from XSteroids?

British Dragon Ipamorelin 5 mg ships from the brand catalogue with secure checkout, US domestic delivery in 3 to 6 days and international delivery in 12 to 26 days. The full range is on the British Dragon page if you want to build a research set around this vial.