Semax - Generic Peptides

Buy Semax by Generic Peptides at XSteroids. Semax is a synthetic heptapeptide derived from the ACTH(4-10) fragment of adrenocorticotropic hormone, developed in Moscow, where it has been a registered medicine since 1994, and the peptide reaches the catalogue from Generic Peptides as lyophilized powder in two vial sizes, 2 mg and 5 mg. Its reputation rests on animal neurochemistry and on Russian clinical work rather than on Western trials. This page sets out what is in the vial, which mechanisms have actually been measured, what was seen and in which species, how the mixing arithmetic works, the amounts quoted in research, and where stacking, storage and legal status stand.

What Semax Is and What You Are Buying

What arrives is a single glass vial of white lyophilized powder, and the pack selector decides whether it carries 2 mg or 5 mg. The vial is sealed with a stopper and a crimp cap, which is the only container the powder meets once it leaves the filling line. Diluent is a separate purchase: bacteriostatic water, sterile water, syringes and swabs never ship with the peptide. Because one page covers both strengths, the milligram figure lives on the pack option rather than in the product name.

The sequence is Met-Glu-His-Phe-Pro-Gly-Pro, abbreviated MEHFPGP, a seven-amino-acid peptide based on the ACTH(4-10) fragment with an extended and stabilised tail. Its formula is C37H51N9O10S, its mass is 813.93 g/mol, its CAS number is 80714-61-0 and its PubChem record is 122178. The name is a Russian abbreviation that stands for seven amino acids. Oral bioavailability is poor, which is why the literature describes intranasal or subcutaneous use. No human half-life has been established, and the registered Russian product is a nasal solution rather than the research powder in this vial.

How Semax Works

Neurotrophins and the BDNF response

The most reproducible finding in animal work is a rapid rise in brain-derived neurotrophic factor and its receptor TrkB in the hippocampus after administration. BDNF is central to synaptic plasticity, and the speed of the response suggests that the peptide acts as a signal rather than as a structural substitute. Serotonergic and dopaminergic systems are also activated in the same experiments, which ties the peptide to mood and motivation circuits rather than to a single transmitter.

Melanocortin receptors and enkephalin breakdown

The exact mechanism is not settled even in the review literature. The leading suggestion involves the melanocortin receptors, where the peptide is described as an antagonist or a partial agonist at MC4 and MC5, the receptors involved in energy balance and stress responses. A second and better-characterised action is inhibition of the enzymes that degrade enkephalins and other regulatory peptides, measured at an IC50 near 10 micromolar in published work shared with Selank. That enzyme blockade can extend the life of endogenous signalling peptides, which is a plausible route for effects that outlast the molecule itself.

Stress protection and behaviour in animals

Animal models show antidepressant-like and anxiolytic-like effects together with protection against chronic stress. These are behavioural endpoints in rodents, and they overlap with the Russian clinical indications, but they cannot be read as proof of a human cognitive benefit.

What to Expect from Semax Research

The marker-level evidence is animal. Rodent studies demonstrate the BDNF and TrkB increase, monoamine activation and behavioural changes. The human evidence is a set of Russian clinical investigations, of which the most often cited concerns ischaemic stroke, where the peptide was reported to improve functional and motor recovery. That study was conducted in a specific clinical setting, is not a large multicentre trial by current standards, and has not been independently replicated in the West.

What is missing matters as much as what exists. There is no Western registration trial, no modern pharmacokinetic profile in humans, and no large randomised study with a prespecified cognitive endpoint. A buyer should expect a compound with decades of use in one country, a plausible neurotrophic mechanism, and an evidence base that a Western regulator would treat as insufficient. Nothing on this page claims that the peptide treats a neurological condition.

Dosing Semax for Research

Mixing a 2 mg or 5 mg vial

Work backwards from the volume you decide to add. Draw 1 ml into the 2 mg vial and each millilitre then carries 2 mg, so a single graduation on the U-100 syringe is 20 mcg and the 10-unit mark lands at 200 mcg; use 2 ml instead and the same vial becomes 1 mg/ml, with the 10-unit mark at 100 mcg. A 5 mg vial behaves the same way at higher numbers: 2 ml makes it 2.5 mg/ml, so 10 units give 250 mcg, and 5 ml makes it 1 mg/ml, so 10 units give 100 mcg. Rotate the vial between your palms, do not shake it, and record the millilitres on the label.

Intranasal and subcutaneous research amounts

Protocols followed in Russian clinics rely on a diluted nasal solution, applied several times daily across roughly two weeks. Research write-ups put each dose between 250 and 1000 mcg, once to three times a day, so daily totals land between 500 and 3000 mcg. No dose-finding trial underpins those figures; they travel as field convention, and with the nasal route technique counts for as much as the quantity drawn.

Stacking Semax With Other Cognitive Peptides

The closest relative is Selank, the other Russian peptide drug, which shares the enkephalin-degradation mechanism; pairing them is a common research convention rather than a studied combination. Sleep-focused plans add DSIP, and MET5 covers the enkephalin angle. In a longevity frame Semax sits beside Epitalon, NAD+, Glutathione and Thymalin. Every pairing above is an assumption rather than a studied combination.

Recovery and Breaks Around Semax

The peptide leaves the testosterone axis untouched, since it is not a hormone, which means a post-cycle protocol has nothing to restore here. The cycle is defined by the clinical scheme: about two weeks of use, followed by a break. If the plan also includes immune-oriented peptides such as Thymosin Alpha-1, run those on their own schedule instead of stacking several immune-active compounds at once, and keep a written log so any change can be attributed to one variable.

Semax Safety and Legal Status

Approved in Russia since 1994

Semax was approved by the Russian Ministry of Health in 1994 and entered the Russian list of vital medicines in 2011. Registered indications there include ischaemic stroke, transient ischaemic attack, encephalopathy, optic nerve atrophy, cognitive impairment and peptic ulcer, together with immune support. Approval stops there: neither the FDA nor the EMA has authorised it, and outside a few markets it exists only as a research peptide rather than a medicine. The vial here is not the registered nasal product.

Cautions and the limits of the safety file

No systematic safety database for Semax exists outside Russia, and the domestic studies are too small to expose a rare-event profile. Local irritation, redness or tenderness can follow a nasal or subcutaneous dose. A person with a diagnosed neurological or psychiatric condition, anyone on prescription medication, and anyone who is pregnant or breastfeeding should not treat a research peptide as medical care; the product is not for anyone under 18.

Anti-doping status

The WADA Prohibited List does not mention Semax, and no federation guidance addresses it either. Read that as an absence of data instead of an approval, because the vial remains an unapproved research peptide that is supplied for laboratory work only.

Semax Storage and Reconstitution Handling

Between uses the sealed powder keeps best in a refrigerator set to 2 to 8 C, out of direct light; for a gap of months, move it to a freezer. After water has been added, refrigerate the solution at 2 to 8 C as well and finish it inside 28 to 30 days without freezing it. Let the vial reach room temperature, swab the stopper with alcohol, and write the reconstitution date on the label together with the volume you used.

Why Buy Semax from XSteroids?

Both Semax vial sizes sit in the Generic Peptides category at XSteroids, next to the other cognitive and sleep compounds. The Selank page covers the second Russian peptide drug, and the DSIP page covers sleep-architecture work. Pick the strength that matches the arithmetic above, then finish the mixed solution inside its 30-day window.