Melanotan II - Generic Peptides

Buy Melanotan II 5 mg and 10 mg by Generic Peptides at XSteroids. A synthetic cyclic analogue of alpha-melanocyte stimulating hormone, melanotan II activates the body's pigment machinery and additionally touches melanocortin receptors linked to appetite and sexual response. Generic Peptides supplies it as 5 mg and 10 mg lyophilized vials. This page covers the chemistry, the single small human study, the reported side effects and the honest reason regulators warn against it.

Statement of fact before anything else: Melanotan II is not approved as a medicine anywhere in the world. Health agencies advise people not to use it. Nothing on this page is a suggestion that it produces a tan safely or at all.

What Melanotan II Is and What You Are Buying

The molecule is a lactam bridged cyclic heptapeptide built from the alpha-MSH fragment 4 to 10, written as Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 alpha-MSH4-10-NH2. It was designed as a tanning agent on the logic that stimulating the body's own melanin production would darken skin without ultraviolet exposure.

Development as a medicine stopped in 2000 in favour of a related compound, bremelanotide, which was later approved for sexual dysfunction in women. Melanotan II is partly metabolised into that compound, which explains why the same peptide appears in both tanning and sexual health discussions.

The item shipped is a single glass vial of lyophilized powder in a 5 mg or 10 mg size, and it arrives without any diluent: bacteriostatic water is bought separately and used after delivery. It is the unapproved research peptide, not a regulated tanning medicine, and it is not sold with any labelling that states a human dose.

How Melanotan II Works at the Receptor

Melanocortin receptors

MC1 receptors on melanocytes drive pigment production, which is the cosmetic effect people chase. MC4, and possibly MC3, receptor activation produces the rest of the profile: appetite suppression, nausea, flushing, yawning and stretching, and spontaneous erections. Because the peptide is not selective, the side effect list was always part of the package.

The only human study, in full

A pilot phase I trial from 1996 enrolled three healthy men. Doses started at 0.01 mg per kg subcutaneously and were escalated by 0.005 mg per kg; 0.03 mg per kg caused grade II somnolence and fatigue in one of two subjects, and mild nausea appeared at most dose levels. Stretching and yawning coincided with erections lasting one to five hours after injection. Two subjects showed increased pigmentation of the face, upper body and buttocks one week after the course. The authors proposed 0.025 mg per kg daily for future phase I work. Three participants is not a safety database.

What to Expect from Melanotan II

Expect very little certainty. The only controlled human data come from a 1996 pilot phase I trial in three healthy men: doses started at 0.01 mg per kg subcutaneously and escalated, 0.03 mg per kg caused grade II somnolence and fatigue in one of two subjects, and mild nausea appeared at most levels. Two subjects showed increased pigmentation of the face, upper body and buttocks about a week after the course. Three participants prove tolerability in three participants, nothing more. There is no formal human pharmacokinetic profile, so the half-life figures quoted online are secondary estimates rather than measured values. Reports of darkening moles and freckles are common, and the link to melanoma is not established: documented cases coincided with heavy sun exposure, which confounds the picture. Agencies such as the TGA advise against using these products because the dosing in them is unstable.

Melanotan II Doses and Reconstitution

Mixing the 5 mg and 10 mg vials

Mixing the 5 mg vial with 1 ml of bacteriostatic water gives 5 mg per ml, and 0.1 ml of that holds 500 mcg, the 10-unit mark on a U-100 insulin syringe. If 2 ml is used instead, the concentration falls to 2.5 mg per ml and 0.1 ml carries 250 mcg, with the same 10-unit reading. The 10 mg vial behaves identically: 2 ml for 5 mg per ml or 1 ml for 10 mg per ml. Rotate the vial gently rather than shaking it, and keep the mixed contents cold and dark.

Reading the study numbers correctly

For illustration only, the published research dose of 0.025 mg per kg would equal 2 mg for an 80 kg adult, which is 0.4 ml of a 5 mg per ml solution, or 40 units on a U-100 syringe. That arithmetic comes from a three person trial from 1996, not from a dosing guideline. No regulator has approved any amount of this peptide for human use.

Stacking Melanotan II With Other Generic Peptides

If the interest is the melanocortin pathway, PT-141 (Bremelanotide) is the approved relative and the more studied molecule. For the hormonal side of libido, Kisspeptin-10 works through the gonadotropin axis instead of melanocortin receptors. Sleep focused research often pairs pigment peptides with DSIP 5 mg, because injections are taken in the evening, and neurological work pairs them with Semax 5 mg. General antioxidant support such as Glutathione 200 mg and NAD+ 250 mg is sometimes added, though none of these combinations has a published interaction study.

Recovery and Cycle Monitoring for Melanotan II

Melanotan II has no suppressive action on the androgen axis and calls for no post-cycle therapy. The real recovery question is monitoring rather than hormonal: because pigmentation changes affect existing moles and can produce new ones, the reported practice is to photograph and track skin changes. Any decision about a changing mole belongs to a dermatologist, not to a research protocol.

Melanotan II Side Effects and Safety Notes

Reported effects

Frequently reported effects are nausea and vomiting, flushing, fatigue, yawning, stretching, appetite loss and spontaneous erections. Reversible darkening of existing moles and freckles is documented, and new naevi are part of the same picture. The 1996 study recorded nausea at most dose levels and grade II somnolence at the highest dose used.

The melanoma question

The evidence is not settled. Reported melanoma cases in users overlapped with heavy sun exposure, and a review concluded the elevated risk is probably explained by more ultraviolet exposure and sun seeking behaviour rather than by a proven direct effect of the peptide. That is a reason to be cautious, not a clean bill of health, and the Skin Cancer Foundation advises against the substance.

Approval status outside the US

Melanotan II has never been licensed. Australia's TGA has warned that tanning products containing melanotan are unapproved and inconsistently dosed, and other national agencies have issued similar notices. In sport, the peptide is not named on the WADA list but falls under the catch-all class S0 for non-approved substances, which several anti-doping bodies state explicitly.

Melanotan II Storage and Stability

Before mixing, the vial sits at 2 to 8 C away from light. After mixing it is kept cold in the same range and used within 28 to 30 days, the usual window for peptides because the manufacturer publishes no stability figure for the solution. Freezing the mixed vial is not advised.

Why Buy Melanotan II from XSteroids?

Buying Melanotan II from Generic Peptides at XSteroids gives you the 5 mg or 10 mg lyophilized vial with transparent pack information on the page. Delivery runs 3 to 6 days within the United States and 12 to 26 days internationally, and the checkout is secure. We publish the regulator warnings alongside the product rather than hiding them.