AICAR - Generic Peptides

Buy AICAR 50 mg and 100 mg by Generic Peptides at XSteroids. The proper name of the compound is acadesine, and it is a nucleoside analogue rather than a peptide; its target is AMP-activated protein kinase, which it activates. Behind it lies a clinical past in cardiac surgery and leukaemia work, a well known mouse endurance experiment and one of the loudest anti-doping stories of recent decades. The brand ships a lyophilized vial, and the sections below lay out the mechanism, the evidence, the fact that no human dose exists and the way each vial is mixed.

The vial counts as laboratory material. AICAR is unlicensed everywhere, and the text is information rather than medical advice.

What AICAR Is and What You Are Buying

Acadesine, known by its INN, is also written as 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, AICA-riboside or simply AICAR. Chemically it is a nucleoside analogue and an activator of AMP-activated protein kinase, the enzyme cells use as a fuel gauge when energy runs low. It was used clinically to protect the heart against ischaemic injury, first appearing in the 1980s as a way to preserve blood flow during surgery, and it is described in treatment of acute lymphoblastic leukaemia and studied in diabetes.

Its development path ended badly: PeriCor Therapeutics licensed acadesine to Schering-Plough in 2007 for phase III work in reperfusion injury during coronary bypass surgery, and the trial was stopped in late 2010 on a futility analysis. Generic Peptides lists a 50 mg and a 100 mg lyophilized vial, which are laboratory formats.

The pack holds a single glass vial of sterile lyophilized acadesine, offered at 50 mg or 100 mg. Diluent, syringes and swabs are not part of it, and since the vial carries tens of milligrams the volumes used for mixing run much larger than they would for a peptide. Nothing arrives pre-mixed; the cake dissolves to a clear solution.

How AICAR Works

AMPK activation

By mimicking AMP, AICAR activates AMPK, which stimulates glucose uptake into cells and raises the activity of p38 mitogen activated protein kinases alpha and beta in skeletal muscle, while suppressing apoptosis by reducing reactive oxygen species inside the cell. Once inside a cell, much of the compound is converted into its active nucleotide form ZMP, which is what does the work.

The mouse endurance experiment

The reputation of AICAR comes from a 2008 study at the Salk Institute in which the compound noticeably improved endurance in mice, apparently by shifting fast muscle fibres towards a more economical oxidative type. In the same programme, combining it with GW501516 switched on roughly 40 percent of the genes that training normally affects in untrained mice. This is rodent data. No human trial has shown that AICAR improves endurance or changes fibre type in people, and the cardiac programme in humans was about protecting the heart, not about performance.

How it differs from the peptides on this site

AICAR is not a peptide at all, so it does not sit on the growth hormone axis and is not paired with the secretagogues the way a GHRH fragment and a ghrelin peptide are. Its action is metabolic: it works through the cell's energy sensor and changes glucose handling and fuel use, which is why it belongs with the fat loss and metabolic research compounds rather than with the growth hormone ones, and why its anti-doping category is different from theirs.

What to Expect With AICAR

What the rodent work showed

The reputation of AICAR comes from a 2008 study at the Salk Institute in which the compound noticeably improved endurance in mice, apparently by shifting fast muscle fibres towards a more economical oxidative type, and in the same programme about 40 percent of the genes that training normally affects were switched on when it was combined with GW501516. The animal protocol behind that line of work used 0.5 mg per gram of body weight daily under the skin for 14 days. These are rodent findings.

What the human work showed

The only large human programme was an intravenous cardiac protection study, and it was stopped on a futility analysis in late 2010. No human trial has shown that AICAR improves endurance or changes fibre type in people, so there is no human performance data to quote. The compound has been used clinically in acute lymphoblastic leukaemia and studied in diabetes, which is where its human exposure comes from, not from sport.

Timeline and what to monitor

Once inside a cell, much of the compound is converted into its active nucleotide form ZMP, and the plasma half-life in human data is estimated at around an hour, with vendor references quoting one to two hours and noting that the human half-life has not been established. The marker to watch is blood glucose, because AMPK activation changes glucose uptake, and there is no validated human dose: vendor conventions range from 1 to 3 mg a day to much larger amounts, with no single protocol.

AICAR Doses and Reconstitution

Mixing the 50 mg and 100 mg vials

The 50 mg vial can be mixed two ways: 2 ml of bacteriostatic water brings it to 25 mg per ml and 2.5 mg in a 0.1 ml volume, while 5 ml brings it to 10 mg per ml and 1 mg per 0.1 ml. For the 100 mg vial, 5 ml of water gives 20 mg per ml and 10 ml gives 10 mg per ml, so a 0.1 ml volume holds 1 mg on that second route. On the U-100 insulin scale, a 0.1 ml amount is drawn as 10 units. Swirl until the powder is gone and place the solution at 2 to 8 C.

Why there is no standard dose

There is no validated human protocol for research use. The mouse work that made AICAR famous used 0.5 mg per gram of body weight daily by subcutaneous injection for 14 days, which does not translate into a sensible human figure, and the only large human programme was an intravenous cardiac protocol that was stopped. Vendor descriptions disagree openly, quoting anything from 1 to 3 mg a day up to much larger amounts. Anyone reading a confident dosing table online is reading a convention, not evidence.

How to Stack AICAR

AICAR is aimed at metabolism rather than at the growth hormone axis, so it sits with the fat loss side of this catalog: AOD 9604 and HGH Frag 176-191 are the fragment peptides studied for fat loss, and Semaglutide covers the incretin route with an approved prescription form behind it. On the tissue side, IGF-1 LR3 and TB 500 are the compounds that research plans usually place around an endurance or recovery study.

Recovery Notes for an AICAR Block

AICAR does not touch the androgen axis, so no post-cycle therapy follows. The recovery question is metabolic instead: AMPK activation shifts cells towards burning fuel, so the practical discipline is around blood glucose and around giving the system a break instead of running continuous cycles. Long term human data do not exist, which is itself an argument for short blocks. Androgen recovery plans belong to androgen cycles, and this brand carries no such products.

AICAR Side Effects and Precautions

Known issues and unknowns

Human safety data come from the cardiac studies, where the compound was given intravenously under supervision, so the risk profile of a subcutaneous research vial is not characterised. AMPK activation affects glucose handling, and anyone on glucose lowering medication or with diabetes has a specific reason for caution. There are no long term human studies of AICAR as a performance compound.

Cautions for handling

Nothing here is medical advice and the vial is research material. Keep it beyond children's reach, dispose of any solution that shows cloudiness or particles, and if a metabolic or cardiac condition is present, take medical advice before handling it at all.

Cold Storage for AICAR

Powder is kept at 2 to 8 C away from light, and a freezer is for untouched vials stored over the long term. A mixed solution holds at 2 to 8 C for at most 28 to 30 days and must not be frozen; if it turns cloudy or particles appear, throw it away.

Why Buy AICAR 50 mg and 100 mg from XSteroids?

AICAR is shipped by XSteroids out of the Generic Peptides catalog, with a secured payment page and tracking on every shipment. US addresses see delivery in 3 to 6 days, addresses overseas in 12 to 26 days. The 50 mg and the 100 mg vial both sit on this page, and the cards below collect the fat loss peptides and the repair compounds that appear beside an AMPK study.