Sermorelin - Dragon Pharma

Buy Sermorelin 5 mg by Dragon Pharma at XSteroids. Sermorelin is the GHRH fragment that was once a marketed prescription medicine - approved, then discontinued - which makes it the most interesting case study in this category. Dragon Pharma supplies it as a 5 mg lyophilized vial. This guide covers the pharmacology, sermorelin dosage practice, the approval history and how it compares with the longer-acting analogues.

Sermorelin is no longer available as an FDA-approved drug, so the information below is educational only.

About Sermorelin by Dragon Pharma

Sermorelin acetate, sold historically as Geref and Gerel, is a peptide analogue of growth hormone-releasing hormone. It consists of 29 amino acids and represents the shortest fully functional fragment of GHRH, which is why it is also called GHRH (1-29) or GRF 1-29. Its role in medicine was as a diagnostic agent to assess GH secretion when investigating growth hormone deficiency.

The approval history is the notable part. Sermorelin was approved by the FDA in 1997 for treating children with growth hormone deficiency or growth failure - but in 2008 the manufacturer discontinued production for commercial reasons, and it has not been available as an FDA-approved drug since. It still circulates in off-label and research settings, which is why vials like this one exist.

How Sermorelin Works

Mechanism of Action

Sermorelin mimics GHRH at the pituitary, the receptor that tells the gland to release growth hormone. Because it acts on the GHRH receptor and not the ghrelin receptor, it does not carry the corticotropic and appetite effects associated with GHRP-2 and GHRP-6 - it is a clean signal for GH release and downstream IGF-1.

Duration

It is a short-acting fragment, with no DAC-style albumin binding to extend it, so its activity window is measured in minutes rather than days. That is the fundamental difference from CJC-1295 DAC, which lasts six to eight days, and the reason sermorelin protocols inject more often.

Sermorelin Dosage and Protocols

Dosing

Because the fragment is short-lived, non-medical protocols dose close to the effect window, typically in small amounts once or twice daily, with the pre-sleep injection timed to the natural GH pulse. The 5 mg vial is reconstituted with bacteriostatic water, and the ratio determines how many units on an insulin syringe equal a given amount.

Reconstitution

Mix the lyophilized powder with bacteriostatic water, aiming the stream at the vial wall rather than the powder, then swirl gently instead of shaking. Label the vial with the date, keep it refrigerated, and treat a punctured multi-dose vial as usable for 28 days after the first puncture.

Sermorelin Side Effects and Safety Context

As a GHRH analogue, sermorelin's safety profile is anchored in its approved history: it was given to children as a prescription treatment, and it was withdrawn for commercial reasons rather than for a safety signal. That is a stronger evidence base than most compounds in this catalog can claim. The caveat is that the current supply is not a regulated pharmaceutical product, and GH secretagogues are restricted in sport under anti-doping rules.

Sermorelin vs CJC-1295, Tesamorelin and Ipamorelin

All three alternatives in this catalog are GHRH-based but differ in duration and status. Sermorelin is the short-acting fragment; CJC-1295 DAC is the albumin-bound long-acting version; Tesamorelin is the one with a current approved indication. On the ghrelin side, Ipamorelin is the selective peptide that pairs well with any of them - including in ready-made blends such as Ipamorelin and Tesamorelin.

Storage Instructions

Store the lyophilized vial in a cool, dry place away from direct light before reconstitution. After mixing with bacteriostatic water, keep the solution refrigerated and use it within the recommended period for peptide solutions. Keep vials out of the reach of children.

Why Buy Sermorelin from XSteroids?

At XSteroids you buy the Dragon Pharma Sermorelin vials directly from the brand catalog, with secure checkout, US domestic shipping in 3 to 6 days and international delivery in 12 to 26 days. Browse the full range on the Dragon Pharma brand page to complete your research protocol.