Sermorelin - Axiolabs

Buy Sermorelin 5 mg by Axiolabs at XSteroids. Sermorelin is a GHRH analogue: the first 29 amino acids of human growth hormone releasing hormone, which is the shortest fragment that keeps the full biological action. Axiolabs supplies it as a lyophilized 5 mg vial for reconstitution with bacteriostatic water. This page covers what the peptide is, how the pituitary response works, mixing and dosing maths, how it pairs with a ghrelin based secretagogue, and the regulatory history that makes this molecule unusual.

Sermorelin is also one of the few peptides in this family that was once an approved medicine, so the human data are older but real. What is missing is any evidence for the anti-aging claims that surround it today.

About Sermorelin by Axiolabs

Sermorelin acetate, also known as GHRH(1-29) or GRF 1-29, is a 29 amino acid polypeptide with the formula C149H246N44O42S. It is a truncated version of the full length human growth hormone releasing hormone and retains the receptor binding and signalling activity of the complete peptide.

The commercial history matters. The product was approved by the FDA in 1997 for children with growth failure caused by growth hormone deficiency. In July 2008 the manufacturer stopped production for commercial reasons rather than safety or efficacy concerns, and the product has not been available as an approved medicine since. Axiolabs delivers the peptide as a research vial, which is the form available today.

How Sermorelin Works

Sermorelin binds the GHRH receptor on pituitary cells and mimics the natural releasing hormone, which makes the gland secrete its own growth hormone. Because the axis keeps its negative feedback through somatostatin, the response is self-limiting: the pituitary releases growth hormone in pulses and then stops, which is why overdose is difficult compared with injecting recombinant hormone directly.

That pulsatile profile is also the reason the peptide is said to avoid tachyphylaxis, the fading of response with repeated use. Human use is documented in two areas. A diagnostic protocol used 1 mcg per kg intravenously and produced a rapid, fairly specific growth hormone response. In treatment, one report describes 30 mcg per kg given subcutaneously once nightly in prepubertal children with idiopathic growth hormone deficiency, with growth velocity gains that held for twelve months in some cases.

Sermorelin Dosage and Reconstitution

Mixing a 5 mg vial

Add 1 to 2 ml of bacteriostatic water to the 5 mg vial for a concentration of 5 mg/ml or 2.5 mg/ml. With 2 ml, 0.1 ml contains 250 mcg, which is 10 units on a U-100 syringe; with 1 ml, 0.1 ml contains 500 mcg. Swirl gently and keep the vial at 2 to 8 C after mixing.

Research and clinical amounts are different

Research write-ups list 200 to 500 mcg subcutaneously once daily, taken 30 to 60 minutes before sleep on an empty stomach, starting at 200 to 250 mcg, over cycles of 12 to 16 weeks with a four to six week break. At 250 mcg a day a 5 mg vial lasts 20 days; at 500 mcg a day it lasts 10 days. Clinical figures were 1 mcg per kg for testing and 30 mcg per kg for paediatric treatment, and they are not interchangeable with the supplier amounts.

How to Stack Sermorelin

Sermorelin is a GHRH analogue, while Ipamorelin 5 mg is a ghrelin receptor agonist. They act on different receptors and are frequently written about as a pair, because one primes the pituitary and the other triggers the release. Tesamorelin 5 mg is the stabilised GHRH analogue with the most human trial data, so it is the natural comparison for anyone weighing fragments.

If direct growth hormone is preferred, AxoTropin HGH supplies the hormone itself rather than stimulating output. The anabolic part of a stack does not change either way, for example Testaplex Testosterone as the base.

Recovery and Post-Cycle Support With Sermorelin

A GHRH analogue does not suppress the androgen axis and needs no post-cycle therapy. If it is combined with a steroid cycle, the support plan covers the anabolic side: Arimiplex 1 mg for estrogen control while on, and Tamoxiplex 20 mg or Clomiplex 50 mg after the last injection.

Judge progress on blood work, particularly IGF-1, rather than on how the first few weeks feel. Growth hormone effects accumulate slowly, and a peptide that works through the body's own feedback loop is deliberately gentle.

Sermorelin Side Effects and Precautions

Documented effects

The approved product was well tolerated, with injection site reactions as the common complaint. Broader reviews of growth hormone releasing peptides list fluid retention, muscle and joint aches and changes in glucose handling as class-level effects, and note that the class can raise prolactin and cortisol, although the feedback loop limits the size of the response.

Banned status

WADA class S2 names growth hormone releasing hormone and its analogues directly, including sermorelin and tesamorelin, and the ban applies at all times. An athlete cannot obtain a therapeutic use exemption for a peptide with no current approved indication.

General precautions

This material is for adult men and is not medical advice. Avoid secretagogues with a pituitary condition, active cancer or uncontrolled diabetes, and keep vials away from children. Never inject a cloudy solution or one that contains particles.

Storing and Handling Sermorelin

Keep the lyophilized powder at controlled room temperature of 15 to 25 C or refrigerated at 2 to 8 C, protected from light, and never freeze the powder. Once mixed, store at 2 to 8 C and use within 30 days, avoiding repeated freeze-thaw cycles.

Why Buy Sermorelin from XSteroids?

At XSteroids you buy Sermorelin directly from the Axiolabs brand catalog, with secure checkout, US domestic shipping in 3 to 6 days and international delivery in 12 to 26 days. The 5 mg vial is listed on this page, and the related products below cover the secretagogue partners and the cycle support that goes with them.