Ipamorelin - Axiolabs

Buy Ipamorelin 5 mg by Axiolabs at XSteroids. Ipamorelin is a synthetic pentapeptide that acts as a selective growth hormone secretagogue: it tells the pituitary to release its own growth hormone instead of supplying hormone from outside. Axiolabs lists it as a lyophilized 5 mg vial that is mixed with bacteriostatic water. This page covers the chemistry, the clinical pharmacokinetics, how a 5 mg vial is mixed, dosing, stacking with a GHRH analogue and the banned status that comes with the whole class.

It is worth knowing from the start that ipamorelin has no approved medical indication. Development stopped after a Phase II trial in postoperative ileus failed, which is why the peptide is sold for research rather than as a medicine.

About Ipamorelin by Axiolabs

Chemically ipamorelin is the pentapeptide Aib-His-D-2-Nal-D-Phe-Lys-NH2, developed from the earlier compound GHRP-1 under the code NNC 26-0161. It binds the ghrelin receptor, also called the growth hormone secretagogue receptor, and it triggers a pulse of growth hormone rather than raising hormone levels continuously.

Axiolabs supplies it as a lyophilized powder in a 5 mg vial with bacteriostatic water for reconstitution. The route is subcutaneous, and supplier guidance suggests an empty stomach, often before sleep, because natural growth hormone output peaks during deep sleep.

How Ipamorelin Works

Ipamorelin stimulates the ghrelin receptor on pituitary cells. Clinical work in healthy male volunteers, published in 1999, measured the response across five infusion rates and found dose-proportional behaviour: a terminal half-life near two hours, clearance of 0.078 L per hour per kg, a steady-state volume of distribution of 0.22 L per kg and a growth hormone peak 0.67 hours after dosing. Half-maximal growth hormone stimulation was reached at 214 nmol/L.

The selectivity is what separates it from the older secretagogues. Profiling in rats and pigs showed no effect on follicle stimulating hormone, luteinising hormone, prolactin or thyroid stimulating hormone, and no rise in ACTH or cortisol, even at doses more than 200 times the effective dose for growth hormone release. Older compounds such as GHRP-2 and GHRP-6 do raise cortisol and prolactin, so a cleaner hormonal footprint is the main selling point.

Ipamorelin Dosage and Reconstitution

Mixing a 5 mg vial

Add 1 to 2 ml of bacteriostatic water to the 5 mg vial for a concentration of 5 mg/ml or 2.5 mg/ml. With 2 ml, 0.1 ml holds 250 mcg, which is 10 units on a U-100 syringe; with 1 ml, 0.1 ml holds 500 mcg. Swirl the vial and keep it at 2 to 8 C once mixed.

Research and supplier amounts

Supplier descriptions list a standard single dose of 200 to 300 mcg and an advanced dose of 400 to 500 mcg, taken once to three times a day, usually before sleep or after training, on cycles of 12 to 16 weeks followed by a four week break. At 250 mcg a day a 5 mg vial lasts 20 days; at 500 mcg a day it lasts 10 days. The clinical study used nanomole infusions, not microgram injections, so the two sets of numbers are not interchangeable.

How to Stack Ipamorelin

Ipamorelin is a ghrelin receptor agonist, while Sermorelin 5 mg is a GHRH analogue that works through a different receptor. Because they act on separate pathways, the pair is often discussed together: the GHRH signal sets the pituitary up and the secretagogue triggers the release. Tesamorelin 5 mg is the longer, more studied GHRH analogue and is the most often cited partner for visceral fat.

Some users still prefer direct growth hormone, AxoTropin HGH, because the dose is exact and does not depend on pituitary response. Whichever route you choose, the anabolic side of a stack stays the same, for example Testaplex Testosterone as the base.

Recovery and Post-Cycle Support With Ipamorelin

Secretagogues do not suppress the androgen axis, so they do not require post-cycle therapy. When they are part of a steroid cycle, the support plan belongs to the anabolic compounds: Arimiplex 1 mg or Exeplex 25 mg for estrogen control while on cycle, then Tamoxiplex 20 mg or Clomiplex 50 mg afterwards.

Because the peptide releases a single hormone pulse per injection, timing does more work than a long half-life would. Keeping injections on an empty stomach and away from meals is the practical rule that most write-ups agree on.

Ipamorelin Side Effects and Precautions

Reported effects and class warnings

A 2026 review of unregulated growth hormone peptides lists fluid retention, joint and muscle aches, injection site reactions, changes in glucose handling and hormonal shifts as class-level concerns. For ipamorelin specifically, the clinical profiling showed no rise in cortisol or prolactin and no change in the other pituitary hormones.

General precautions

This material is for adult men and is not medical advice. Anyone with a pituitary condition, active cancer or diabetes should not use secretagogues without medical supervision. Keep the vial out of reach of children, and never inject a solution that is cloudy or contains particles.

Storing and Handling Ipamorelin

Store the lyophilized powder at controlled room temperature of 15 to 25 C or in the refrigerator at 2 to 8 C, away from light, and never freeze the powder. After reconstitution keep it at 2 to 8 C and use it within 30 days, avoiding repeated freeze-thaw cycles.

Why Buy Ipamorelin from XSteroids?

At XSteroids you buy Ipamorelin directly from the Axiolabs brand catalog, with secure checkout, US domestic shipping in 3 to 6 days and international delivery in 12 to 26 days. The 5 mg vial is on this page, and the related products below cover the GHRH partners and the on-cycle support that usually goes with a secretagogue.