Mazdutide - Dragon Pharma

Buy Mazdutide Peptide 10 mg by Dragon Pharma at XSteroids. Mazdutide is the dual GLP-1 and glucagon agonist developed by Eli Lilly and Innovent Biologics, and it is the first compound of its class to reach an approved market. Dragon Pharma supplies it as a 10 mg lyophilized vial. This guide covers the mechanism, the trial and approval timeline, mazdutide dosage practice and reconstitution.

Mazdutide is a prescription medicine in China and an investigational drug elsewhere, so the information below is educational only.

About Mazdutide by Dragon Pharma

Mazdutide, also coded IBI362 or LY3305677, is an analogue of oxyntomodulin, the natural gut peptide that signals through both the GLP-1 and glucagon receptors. That structural origin is worth noting because it separates mazdutide from survodutide, which reaches the same two receptors but is built as a glucagon analogue instead.

It is administered by injection on a once-weekly schedule and is being developed jointly by Eli Lilly and Innovent Biologics.

How Mazdutide Works

Two Receptors at Once

GLP-1 receptor activation reduces appetite and slows gastric emptying. Glucagon receptor activation increases energy expenditure and fat oxidation. Together they produce weight loss through appetite control plus a metabolic rate component, which is the pharmacological argument for this class over single GLP-1 drugs.

Trial and Approval Timeline

Mazdutide has moved through multiple phase 3 studies. In May 2025, phase 3 results showed that once-weekly mazdutide produced clinically relevant reductions in body weight in Chinese adults with overweight or obesity. In June 2025, the injectable form was approved for marketing in China - the first approval for a dual GLP-1/glucagon agonist. In most other markets it remains investigational.

Mazdutide Dosage and Reconstitution

Dosage Practice

Clinical work has used weekly injections in escalating steps, with phase 1b studies testing doses such as 9 mg and 10 mg in people with type 2 diabetes and with obesity. In research use the amount is measured in micrograms, which means the reconstitution ratio - not the vial size - determines how many units on an insulin syringe match a given dose.

Reconstitution

Mix the lyophilized powder with bacteriostatic water, aiming the stream at the vial wall, then swirl gently instead of shaking. Label the vial with the date, keep the solution refrigerated, and treat a punctured multi-dose vial as usable for 28 days.

How Mazdutide Compares to Other Metabolic Peptides

Mazdutide is GLP-1 plus glucagon, as are survodutide and, with a third receptor added, retatrutide. Semaglutide covers GLP-1 alone, tirzepatide pairs GLP-1 with GIP, and cagrilintide works through amylin receptors. In a cutting phase these are often combined with thermogenics such as Clenbuterol or thyroid support like T3.

Mazdutide Side Effects and Precautions

The effects reported across the GLP-1 and glucagon agonist class are gastrointestinal: nausea, vomiting, diarrhoea, constipation and reduced appetite, and they are dose-dependent and typically strongest while the dose is escalating. Because glucagon signalling affects glucose and liver metabolism, blood work belongs in any plan. Persistent severe abdominal pain warrants stopping and seeking medical attention.

Storage Instructions

Store the lyophilized vial in a cool, dry place away from direct light before reconstitution. After mixing with bacteriostatic water, keep the solution refrigerated and use it within the recommended period for peptide solutions. Keep vials out of the reach of children.

Why Buy Mazdutide from XSteroids?

At XSteroids you buy the Dragon Pharma Mazdutide vials directly from the brand catalog, with secure checkout, US domestic shipping in 3 to 6 days and international delivery in 12 to 26 days. Browse the full range on the Dragon Pharma brand page to complete your metabolic research stack.